Nghọta ọhụrụ n'ime Cell Killer Cell nke Ọrụ mgbochi ọrịa kansa

Oncolytics Biotech® Inc. taa kwuputara mbipụta nke preclinical na data ndidi na pelareorep na akwụkwọ akụkọ nyocha nke ndị ọgbọ Immunology. E bipụtara akwụkwọ akụkọ ahụ, nke akpọrọ "Ọgwụgwọ nje Oncolytic dị iche iche na-emetụta CD56dim na CD56bright NK cell subsets na vivo ma na-achịkwa ụdịdị ọrụ mmadụ NK cell," ka ebipụtara na mmekorita ya na ndị nyocha n'ọtụtụ ụlọ ọrụ ama ama, gụnyere Mahadum Leeds School of Medicine na Institute of Cancer Research, London. Enwere ike ịchọta njikọ na akwụkwọ ahụ site na ịpị ebe a.

Akọwara n'akwụkwọ a bụ ọmụmụ ihe in vitro na-enyocha mmetụta pelareorep na mkpụrụ ndụ Natural Killer (NK) yana nyocha nke nlele ọbara sitere na ndị ọrịa nwere metastases imeju colorectal nke a na-ewere tupu na mgbe ọgwụgwọ pelareorep gasịrị. Nsonaazụ gosiri ọgwụgwọ pelareorep butere ịgbalite mkpụrụ ndụ NK, bụ ndị a maara na-egbu mkpụrụ ndụ kansa ozugbo na-akpali akpali mgbochi mgbochi tumor. A na-ahụ mmetụta bara uru nke pelareorep ma na nlele ndị ọrịa na in vitro ma bụrụ ndị a na-agbanye ya site na akara 1 interferon (IFN-1), ụzọ isi na-etinye aka na immunoregulation na njirimara cell tumor.

"Nsonaazụ ndị a dị mkpa n'ihu na-egosipụta ma usoro ihe omume immunologic nke pelareorep na nke na-agbanwe agbanwe, ma anyị nwere obi ụtọ ka e bipụta ha n'akwụkwọ akụkọ a ma ama nke ndị ọgbọ nyochara," ka Dr. Matt Coffey, Onye isi oche na onye isi nchịkwa nke Oncolytics Biotech kwuru. ngalaba-ede akwụkwọ. "Mgbe anyị na-elele nchoputa ndị a, yana data nyocha ụlọ ọgwụ gara aga na-egosi ike pelareorep ime ka mkpụrụ ndụ T rụọ ọrụ ka ọ na-akwalite ntinye ha n'ime etuto ahụ, anyị na-ahụ pelareorep na-ebuga nzaghachi mgbochi ọrịa kansa siri ike, ahaziri ahazi nke ma usoro ahụ ji alụso ọrịa ọgụ na-emegharị ahụ. Na-atụ anya, anyị ga-aga n'ihu na-akwalite mmetụta immunotherapeutic nke pelareorep ka anyị na-aga n'ihu na mmepe ya dị ka teknụzụ na-enye ohere maka ọtụtụ akụkụ nke immunotherapeutic agents na ọrịa kansa ara na ihe ngosi oncologic ndị ọzọ nwere mkpa dị elu.

Ihe nlele ndị ọrịa nyochara na mbipụta ahụ sitere na nyocha ụlọ ọgwụ emechara nke windo ohere ohere na-enyocha pelareorep na ndị ọrịa cancer colorectal nwere metastases imeju. Ndị ọrịa natara n'etiti otu na ise doses nke pelareorep tupu a na-eme atụmatụ ịwa ahụ iji megharịa metastases. A na-ewere ihe nlele ọbara ma tupu oge na ọtụtụ oge mgbe ọgwụgwọ pelareorep gasịrị. Nkọwa ndị ọzọ gbasara nnwale ahụ, yana nsonaazụ akọpụtara na mbụ, dị na mbipụta ndị ọgbọ nyochachara.