Agwọ onye ọrịa mbụ nwere ọbara mgbali elu akwara akwara

Respira Therapeutics, Inc. mara ọkwa taa na onye ọrịa mbụ na United States ejiriwo ọgwụ ahụ mee ihe na nyocha multicenter nke onye na-emepụta ngwaahịa ya, RT234-PAH (vardenafil a na-enye ya dị ka ọgwụgwọ akọrọ). Nnwale VIPAH-PRN 2b (Vardenafil Inhaled for Pulmonary Arterial Hypertension - PRN) ga-agụnye ndị otu abụọ na-eme ihe na-enweta RT234 dị ka otu doses a na-enye site na Axial Oscillating Sphere dry powder inhaler. Emebere ọmụmụ ahụ iji nyochaa nchekwa na mbido mbụ nke RT234 iji meziwanye mgbaàmà episodic na ike mmega ahụ na ndị a na-agwọ maka ọbara mgbali elu pulmonary arterial (PAH) na New York Heart Association (NYHA) na-arụ ọrụ Class II-III.     

Carol Satler, PhD kwuru, "Mmalite nke nnwale ụlọ ọgwụ a na-anọchite anya ihe dị mkpa dị mkpa maka Respira na bụ nzọụkwụ ọzọ dị oke mkpa n'inye ndị ọrịa nwere PAH ọgwụgwọ siri ike iji jikwaa mkpụmkpụ ume ha, nke na-egbochi ha ịrụ ọrụ kwa ụbọchị," Carol Satler, PhD kwuru. , MD, President na Chief Medical Officer nke Respira. "Ndị mmadụ na-arịa ọrịa a na-agwụ ike na nke siri ike bụ ndị a na-eji ọgwụgwọ nlekọta na-agwọ ọrịa ka na-enwe mmetụta nke mkpụmkpụ ume, ike ọgwụgwụ na enweghị ike imega ahụ, na ugbu a enweghi ọgwụgwọ mmalite ngwa ngwa dị maka 'dị mkpa' iji belata ihe omume ndị a. ”

"Ikwenye ndị ọrịa PAH ka ha na-arụsi ọrụ ike bụ isi ihe na ahụike anụ ahụ na nke uche," ka Raymond L. Benza, MD, Onye isi nke Ngalaba Na-ahụ Maka Ọrịa Obi na Ụlọ Ọrụ Na-ahụ Maka Ọgwụ na Ohio State University Wexner kwuru. "Ugbu a site na nyocha nke RT234, anyị na-enyocha ikike anyị nwere ịkwalite mmega ahụ mgbe onye ọrịa chọrọ ya. O nwere ike ịbụ nnukwu nzọụkwụ n'ọgụ anyị na ọrịa a."

Nnwale VIPAH-PRN 2b (RT234-PAH-CL202) bụ nyocha mmụba nke dose iji nyochaa nnukwu mgbanwe na mgbaàmà post dosing nke RT234 na isiokwu nwere PAH. A na-eche na inhaled RT234 (vardenafil inhalation ntụ ntụ) nwere ike inye uru ọgwụgwọ maka nnukwu ojiji na ndị ọrịa nwere Òtù Ahụ Ike Ụwa (WHO) Group 1 Pulmonary Hypertension (PH) (Pulmonary Arterial Hypertension [PAH]) iji meziwanye ikike mmega ahụ na ịrụ ọrụ na mmemme nke ibi ndụ kwa ụbọchị, yana ibelata mgbaàmà mgbakasị ahụ (dịka ọmụmaatụ, dyspnea) na mmetụta ha na-emebi emebi na ogo ndụ.