Ọnwụnwa ụlọ ọgwụ ọhụrụ nke 1 maka Tumor ụmụaka CNS

EpicentRx, Inc., ụlọ ọrụ ọgwụ na ngwaọrụ ụlọ ọgwụ, yana mmekorita ya na Texas Children's Cancer Center na Houston, kwupụtara taa mmalite nke ọmụmụ ihe nke 1 iji nyochaa nchekwa na uru nke obere molekul ya, RRx-001, gbakwunyere. irinotecan na temozolomide maka ndị ọrịa ụmụaka nwere etuto ahụ siri ike ma ọ bụ nke na-aga n'ihu nke ukwuu. Ọmụmụ ahụ, PIRATE (NCT04525014) bụ ndị dọkịta Holly Lindsay na Patricia Baxter chepụtara ma mepụta ya na Texas Children's Cancer Center ma ga-edebanye aha ndị ọrịa 1 ruo 21 afọ nwere ụbụrụ isi na-emegharị ma ọ bụ na-aga n'ihu ma ọ bụ ụbụrụ ụbụrụ na-adịghị mma na ụbụrụ siri ike, ewezuga. lymphomas.        

Usoro ọmụmụ maka nnwale PIRATE dabere n'ọtụtụ nnwale ụlọ ọgwụ ndị bu ụzọ gosi na RRx-001 na-abawanye nnyefe chemotherapy na nnabata na etuto ahụ. Nnwale ụlọ ọgwụ nke 1 nke a na-akpọ G-FORCE (NCT02871843) na usoro 1/2 nke ụlọ ọgwụ a na-akpọ BRAINSTORM (NCT02215512) gosipụtara nchekwa nke RRx-001 yana ihe akaebe nke uru ahụike na ndị okenye nwere glioblastoma ma ọ bụ GBM na ụbụrụ. metastases, n'otu n'otu.

A na-ahazi mkpụrụ ndụ kansa iji gaa n'anụ ahụ dị iche iche na ahụ, ebe ha na-eguzobe ihe mgbochi iji gbochie nnyefe ọgwụ. Otu n'ime echiche nke ikpe a bụ na RRx-001 nwere ike "na-edozi" microenvironment tumor, na-eme ka ụbụrụ tumor dịkwuo mma maka nnyefe nke irinotecan na temozolomide ka uru ha na-abawanye ka ọ na-eme ka mkpụrụ ndụ na-adịghị ike dị ka macrophages na-aga agha ahụ. site na mmegide ya nke akara CD47 " erila m ". Echiche ọzọ bụ na RRx-001 ga-echebe anụ ahụ nkịtị, ma ọ bụghị etuto ahụ, site na nsị nke irinotecan na temozolomide.

"Anyị nwere obi ụtọ ịmalite ọmụmụ ihe a na RRx-001 na iji guzobe ọrụ ya dị ka ọgwụgwọ nwere ike ịgwọ ọrịa ụbụrụ CNS ụmụaka," Tony R. Reid, MD, Ph.D., Chief Executive Officer of EpicentRx kwuru. “Nnwale a agaraghị ekwe omume ma ọ bụrụ na enweghị nkwado obi ọkụ nke Texas Children's Cancer Center. Dị ka nnwale ụlọ ọgwụ na etuto CNS toro eto na-atụ aro na RRx-001 nwere ike inye uru na ọnụ ọgụgụ ụmụaka, mmekorita anyị na ha bụ ihe akaebe na ntinye aka nke ụlọ ọrụ a ịgbaso data ebe ọ bụla ọ na-eduga.

"Enwere ihe na-akpali akpali na ihe gbasara ahụike maka nchekwa na ịdị irè nke RRx-001 na ụbụrụ CNS," Dr. Holly Lindsay, MD, Prọfesọ na-enyere aka, Ngalaba Pediatrics, Ngalaba Hematology-Oncology, Baylor College of Medicine and lead kwuru. Onye nyocha. "Mmetụta nke etuto CNS na ụmụaka na-esi ike ịgwọ ọrịa, anyị na-atụkwa anya na ọmụmụ PIRATE ga-emepụta data bara uru iji nyere aka mee ka mkpebi ọgwụgwọ n'ọdịnihu."