Ọdịiche Lambda: Ọgwụ mgbochi yana ọ na-efe efe karịa?

NKWASỊTA

Mbufe SARS-CoV-2 dị elu na-eme na Chile n'agbanyeghị mkpọsa ịgba ọgwụ mgbochi kpụ ọkụ n'ọnụ, nke na-adaberekarị na ọgwụ mgbochi nje na-adịghị arụ ọrụ sitere na Sinovac Biotech yana ruo n'ókè dị nta na ọgwụ mgbochi mRNA sitere na Pfizer / BioNTech na ọgwụ mgbochi vector na-anaghị emegharị ahụ. Oxford/AstraZeneca na Cansino Biologicals.

Ọwa ikpeazụ a kọrọ na mba ahụ bụ nke SARS-CoV-2 dị iche iche Gamma na Lambda, bụ nke ekesara dị ka ụdị nchegbu ọtụtụ ọnwa gara aga na nke WHO ghọtara na nso nso a dị ka ụdị mmasị nke WHO. Ọ bụ ezie na ụdị Gamma nwere mmụgharị iri na otu na protein spike gụnyere ndị nọ na ngalaba nnabata nnabata (RBD) jikọtara ya na mmụba ACE11 njikọ na nje (N2Y) ma ọ bụ mgbapụ mgbochi (K501T na E417K) protein spike nke ụdị Lambda nwere ihe pụrụ iche. ụkpụrụ nke 484 mutations (Δ7-246, G252V, T75I, L76Q, F452S, D490G, T614N) nke L859Q yiri mgbanwe L452R nke a kọrọ na Delta na Epsilon variants.

Egosiputa ngbanwe nke L452R inyefe mgbochi mgbochi na mgbochi monoclonal (mAbs) yana plasma convalescent.

Ọzọkwa, mmụgharị L452R egosila na ọ na-abawanye nje virus yana data anyị na-atụ aro na ngbanwe L452Q dị na ụdị Lambda nwere ike inye ụdị ihe ndị ahụ akọwara maka L452R. N'ụzọ na-akpali mmasị, ihichapụ 246-252 na ngalaba N-terminal (NTD) nke Lambda Spike dị na ebe antigenic na ya mere, ihichapụ a nwekwara ike inye aka na mgbapụ mgbochi. Ọzọkwa, ngbanwe F490S ejikọtawokwa na mgbapụ na sera convalescent.

N'ikwekọ n'ihe ndị a gara aga, nsonaazụ anyị na-egosi na protein spike nke ụdị Lambda na-enye ụzọ mgbapụ na mgbochi mgbochi nke ọgwụ mgbochi CoronaVac kpatara. Ma ụdị Lambda na-agbanarị na nzaghachi cellular egosiri na CoronaVac na-ebute ya ka amabeghị.

Anyị chọpụtakwara na protein spike nke ụdị Lambda gosipụtara mmụba na-efe efe ma e jiri ya tụnyere protein spike nke ụdị Alfa na Gamma, ha abụọ nwere mmụba na mbufe ọrịa.

Ọnụ, data anyị na-egosi na nke mbụ na mmụgharị dị na protein spike nke Lambda variant na-enye ohere ịgbapụ na mgbochi mgbochi yana ịba ụba ọrịa. Ihe akaebe a gosipụtara ebe a na-ewusi echiche ahụ ike na nnukwu mkpọsa ịgba ọgwụ mgbochi ọrịa na mba ndị nwere oke mgbasa ozi SARS-CoV-2 ga-esonyere ya na nyocha nke mkpụrụ ndụ ihe nketa iji chọpụta ngwa ngwa nje virus ọhụrụ na-ebu mmụba spike yana ọmụmụ ebumnuche iji nyochaa mmetụta nke ndị a. Mmụba n'ụdị mgbapụ na mgbanarị ọgwụ mgbochi ọrịa.

COVID-19 na-aga n'ihu ngwa ngwa. Enwere ike ịhụ nke a na Hawaii ebe ọnụ ọgụgụ dị ala wee wụpụ ka ọ dekọọ elu na ọganihu njem nlegharị anya.