Ụzọ Ọhụrụ Na-aga Ọsọ Ọsọ Nchọpụta Nchọpụta COVID-19 Edochiri na Ọlaedo

Ndị ọrụ nyocha jiri ọla nanoparticles ọla edo mepụta usoro nyocha mkpụrụ ndụ ọhụrụ nke na-ebelata nke ukwuu oge achọrọ maka nchọpụta COVID-19.

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Mgbasa ngwa ngwa nke COVID-19, ọrịa nke nje SARS-CoV-2 kpatara, ebutela nsogbu ahụike ọha na eze gburugburu ụwa. Nchọpụta mbụ COVID-19 na ikewapụ ya bụ isi maka ịchịkwa mgbasa ọrịa yana ichekwa ndị na-adịghị ike. Ọkọlọtọ dị ugbu a maka nyocha COVID-19 bụ reverse transcriptase-polymerase chain reaction (RT-PCR), usoro nke a na-achọpụta mkpụrụ ndụ ihe nketa na-efe efe mgbe ha nwesịrị ọtụtụ okirikiri nke mmụba. Otú ọ dị, usoro a na-ewe oge, na-emepụta nyocha nyocha n'ofe ụlọ ọrụ nyocha ma na-eduga n'oge nyocha.      

N'ime nnyocha e bipụtara na nso nso a na Biosensors na Bioelectronics, ndị nchọpụta si Korea na China ewebatala usoro nanotechnology ọhụrụ nke nwere ike belata oge achọrọ maka nyocha COVID-19. Igwe ihe nchọta nke Raman nke elu ha (SERS) -PCR akwadoro - nke a kwadebere site na iji ọla edo nanoparticles (AuNPs) n'ọgba nke Au 'nanodimple' substrates (AuNDS) -nwere ike ịchọpụta mkpụrụ ndụ ihe nketa nje mgbe naanị 8 cycles nke nkwalite. Nke ahụ bụ ihe fọrọ nke nta ka ọ bụrụ otu ụzọ n'ụzọ atọ nke ọnụ ọgụgụ a chọrọ na RT-PCR.

“RT-PCR a na-emekarị dabere na nchọta nke mgbaàmà fluorescence, yabụ achọrọ awa 3-4 iji chọpụta SARS-CoV-2. Ọsọ a ezughi oke n'ịtụle etu COVID-19 si agbasa ngwa ngwa. Anyị chọrọ ịchọta ụzọ isi belata oge a opekata mpe ọkara,” ka Prọfesọ Jaebum Choo na-ekwu, na-akọwa ihe mkpali mere ọmụmụ ihe ahụ. Ọ dabara nke ọma, azịza ya adịchaghị anya. N'ime nyocha gara aga nke e bipụtara na 2021, ndị otu Prọfesọ Choo ewepụtala usoro nchọpụta ọhụụ nke ndị AuNP na-emepụta akara ngosi SERS dị elu n'otu n'otu na oghere nke AuNDS site na usoro akpọrọ DNA hybridization. Dabere na nchọpụta gara aga, Prọfesọ Choo na ndị otu ya mepụtara usoro SERS-PCR ọhụrụ maka nyocha COVID-19.

Nyocha SERS-PCR nke emepụtara ọhụrụ na-eji akara SERS iji chọpụta “akwa DNA”—obere nyocha DNA nke ji nwayọọ nwayọọ na-agbada n'ihu mkpụrụ ndụ ihe nketa nje. Ya mere, n'omume sitere na ndị ọrịa dị mma maka COVID-19, ntinye nke DNA àkwà mmiri (na ya mere akara SERS) na-ebelata na-aga n'ihu na usoro PCR na-aga n'ihu. N'ụzọ dị iche, mgbe SARS-CoV-2 na-anọghị, akara SERS na-agbanwe agbanwe.

Ndị otu ahụ nwalere ịdị irè nke sistemụ ha site na iji akara abụọ nnọchite anya SARS-CoV-2, ya bụ, protein envelopu (E) na RNA-based RNA polymerase (RdRp) genes nke SARS-CoV-2. Mgbe achọrọ okirikiri 25 maka nchọpụta dabere na RT-PCR, ikpo okwu SERS-PCR dabere na AuNDS chọrọ naanị okirikiri asatọ, na-ebelata nke ukwuu oge nnwale. "Ọ bụ ezie na nsonaazụ anyị bụ nke mbụ, ha na-enye ihe akaebe dị mkpa maka izi ezi nke SERS-PCR dị ka usoro nyocha. Usoro SERS-PCR nke dabere na AuNDS bụ ikpo okwu nyocha mkpụrụ ndụ ọhụrụ na-ekwe nkwa nke nwere ike belata oge achọrọ maka nchọpụta mkpụrụ ndụ ihe nketa ma e jiri ya tụnyere usoro RT-PCR. Enwere ike ịgbasa ihe nlereanya a site n'itinye onye na-emepụta ihe na-akpaghị aka iji mepụta usoro nchọpụta mkpụrụ ndụ nke ọgbọ ọzọ," ka Prof. Choo na-akọwa.

N'ezie, SERS-PCR nwere ike ịbụ ngwa ọrụ dị mkpa na ngwa agha anyị megide ọrịa COVID-19. Ọ nwekwara ike ịmepụta mgbanwe ngbanwe na ngalaba nyocha nke mkpụrụ ndụ ihe nketa, na-agbanwe ka anyị si achọpụta ọrịa na-efe efe na ịlụso ọrịa ọgụ n'ọdịnihu.

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Onye nchịkọta akụkọ nke eTurboNew bụ Linda Hohnholz. Ọ dabere na eTN HQ na Honolulu, Hawaii.

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