Ihe mgbochi ọhụrụ na-ewepụ Omicron na Variants nke ọma

Sorrento Therapeutics, Inc. taa kwupụtara mwepụta nke data ọhụrụ na Omicron variant neutralizing antibody (nAb) STI-9167, COVISHIELD, ihe mgbochi ọkwa dị elu achọpụtara ma mepụta maka ule ụlọ ọgwụ na mmekorita na-aga n'ihu n'etiti ndị na-ahụ maka ọgwụ nje na ndị na-ahụ maka nje na Sorrento na Icahn. Ụlọ Akwụkwọ Ọgwụ na Ugwu Saịnaị na New York, NY.

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Nnwale na-ejikọta protein spike na nnwale mkpochapụ site na iji nje na-anọchite anya SARS-CoV-2 iche iche nke nchegbu (VOCs) ejirila STI-9167 mechaa, a hụrụ nAb a ka ọ jikọtara ya na mmekọrịta dị elu ma na-enye ọrụ nkwụsịtụ siri ike (Omicron IC50). = 25ng/ml). N'ihe dị mkpa pụtara, STI-9167 pụrụ iche ma e jiri ya tụnyere ule nke EUA kwadoro SARS-CoV-2 nAbs na njide na mkpochapụ na-echekwa megide ụdị Omicron na Omicron (+ R346K) na-apụta, ụdị agbụrụ Omicron na-arịwanye elu nke na-abawanye. na-etinye koodu mgbakwunye R346K Spike protein mutation. Na mgbakwunye, a na-enye STI-9167 na obere dose (5mg/kg) site na ụzọ intranasal ma ọ bụ ụzọ intravenous nyere nchebe siri ike megide akara ahụike nke ọrịa sitere na ụdị Omicron dị na K18-hAce2 transgenic òké ụdị nke COVID-19, na-egbochi ibu ibu. mfu na ibelata titers nje na ngụgụ ruo ọkwa a na-apụghị ịchọpụta.

"Ọgbọ na njirimara nke STI-9167 nAb na-egosipụta nnukwu mmekorita dị n'etiti ndị ọkà mmụta sayensị nke Ugwu Saịnaị na Sorrento iji dozie nsogbu ahụike zuru ụwa ọnụ," Domenico Tortorella, PhD, Prọfesọ nke Microbiology na Icahn Ugwu Saịnaị kwuru.

"Anyị ahọrọla ọgwụ mgbochi STI-9167 sitere na nnukwu ụdị mgbochi SARS-CoV-2 dị iche iche na-egbochi mgbochi nke anyị mepụtara na ụlọ nyocha anyị. O gosiputara mwepu nke kachasi ike megide ihe niile ama ama SARS-CoV-2 kewapụ na iche iche nke nchegbu, gụnyere ụdị Omicron na Omicron (+ R346K) na-adịbeghị anya, "kwuru J. Andrew Duty, PhD, Prọfesọ na-enyere aka na Microbiology na Onye isi nke Ụlọ Ọrụ Na-ahụ Maka Ọgwụ Na-ahụ Maka Ọgwụ Na-ahụ Maka Ọgwụgwọ na Icahn Ugwu Saịnaị.

Mike A. Royal, MD, JD, MBA, Chief Medical Officer kwuru na "EUA kwadoro ugbu a nAbs belatara ma ọ bụ na-anọghị na njikọ na nkwụsịtụ ọrụ megide omicron/omicron (+ R346K) na-eme ka ha ghara ịkwado mkpa ụlọ ọgwụ ugbu a." Sorrento. "NAbs ọzọ na-achọsi ike n'oge na-adịghị anya, karịsịa maka ndị na-ahụ maka ụmụaka nke yiri ka ọ nọ n'ihe ize ndụ dị ukwuu maka ọrịa omicron siri ike na ụlọ ọgwụ. Usoro COVIDROPS intranasal anyị na-ebuga nAbs anyị n'okporo ụzọ ikuku dị n'elu ebe Omicron yikarịrị ka ọ ga-ezubere ma na-eto eto, yana dịka nke na-adịghị emerụ ahụ, dị mfe iji nye ọgwụgwọ, ọ dị mma maka ụmụaka. Anyị amalitela ịgwọ ụmụaka nwere COVIDROPS (nwere STI-2099) na Mexico ebe ụdị delta ka juru ebe niile. Site na ọmụmụ ihe nke abụọ na US, United Kingdom na Mexico, anyị ahụla profaịlụ nchekwa dị mma maka nnyefe intranasal nke nAbs anyị wee na-atụ anya nsonaazụ yiri ya na COVIDROP (ya na STI-2).

Mark Brunswick, PhD, SVP na Onye isi nke Regulatory Affairs and Quality na Sorrento kwuru, "Ugbu a anyị enweela ahụmịhe na iwebata ọtụtụ ọgwụgwọ COVID-19 n'ime ụlọ ọgwụ wee na-aga n'ihu ọtụtụ n'ime usoro nke abụọ na / ma ọ bụ mmepe dị mkpa." "Anyị nọ n'ọnọdụ nke ọma iwepụta COVISHIELD ngwa ngwa site na ọkwa IND na n'ụlọ ọgwụ ma na-atụ anya itinye akwụkwọ IND a dị mkpa n'ọnwa na-abịa."

Dr. Henry Ji, onye isi oche na onye isi oche nke Sorrento, kwuru, sị: “Ọrụ ndị otu na-arụ na Sorrento na Ugwu Saịnaị ewepụtala ọgwụ mgbochi pụrụ iche nwere ihe nchebe pụrụ iche ma baa uru megide Omicron na SARS-CoV-2 VOC ndị ọzọ. Ihe mgbochi mgbochi COVISHIELD anyị bụ onye kacha mma na klaasị na onye kachasị elu maka ịlụso Omicron ọgụ na Omicron (+ R346K) VOC na-apụta. Anyị na-agbasi mbọ ike idobe ọgwụ mgbochi a maka ndị ọrịa COVID ma nwee ntụkwasị obi na ụzọ anyị ga-eweta ọgwụgwọ ọgwụgwọ dị mma ọ bụghị naanị n'oge dị nso kamakwa ka ọrịa na-aga n'ihu na-amalite. "

Edebere ihe odide preprint na Jenụwarị 19, 2022 ma a ga-ebipụta ya n'oge na-adịghị anya na biorxiv.org.

Emepụtara ọgwụ mgbochi mgbochi nke akọwara n'ime ụlọ nyocha dị n'Ugwu Saịnaị ma nye ya ikike naanị maka ọgwụgwọ Sorrento. Ndị nkuzi ugwu Saịnaị na ugwu Saịnaị nwere mmasị ego na ọgwụgwọ Sorrento.

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