Pịa ebe a ma ọ bụrụ na nke a bụ ntọhapụ mgbasa ozi gị!

Genital Psoriasis: Nsonaazụ nke ọmụmụ ọhụrụ

Amgen taa kwuputara nsonaazụ dị elu site na nnwale DISCREET, usoro nke 3, multicenter, randomized, placebo-controlled, ọmụmụ ihe abụọ kpuru iji chọpụta ịdị irè nke Otezla® (apremilast) na ndị okenye nwere psoriasis genital na-agafeghị oke ma na-agafe agafe. nnukwu plaque psoriasis.

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Ọmụmụ ihe ahụ gosiri na ọnụ Otezla 30 mg ugboro abụọ kwa ụbọchị nwetara mmụba bara uru nke ụlọ ọgwụ na nke ọnụ ọgụgụ dị ukwuu, ma e jiri ya tụnyere placebo, na njedebe bụ isi nke nzaghachi nzaghachi Global Assessment of Genitalia (sPGA-G) gbanwetụrụ (akọwapụtara dị ka akara sPGA-G). nke doro anya (0) ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke doro anya (1) yana opekata mpe mbelata 2 site na ntọala) na izu 16.      

Tụkwasị na nke ahụ, a na-ezutekwa ngwụcha ngwụcha abụọ niile nwere ọganihu bara uru na nke dị ịrịba ama na nzaghachi Genital Psoriasis Itch Numerical Rating Scale (GPI-NRS) (akọwapụtara dị ka opekata mpe mbelata 4 site na ntọala na GPI-NRS ihe akara n'ime Genital Psoriasis Symptoms. maka isiokwu ndị nwere akara mmalite nke ≥ 4); emetụta akụkụ ahụ (BSA) mgbanwe site na ntọala; Dermatology Life Quality Index (DLQI) gbanwere site na ntọala; na nzaghachi nyocha zuru ụwa ọnụ nke dibịa (sPGA) (akọwapụtara dị ka akara sPGA nke doro anya (0) ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ nke doro anya (1) ma ọ dịkarịa ala mbelata 2 site na ntọala) na izu 16 na Otezla vesos placebo.

Ụdị na ọnụego nke ihe ọjọọ ndị a hụrụ na ikpe a kwekọrọ na profaịlụ nchekwa nke Otezla mara. Ihe ọjọọ a na-akọkarị bụ nke mere na opekata mpe 5% nke ndị ọrịa na otu ọgwụgwọ ọ bụla bụ afọ ọsịsa, isi ọwụwa, ọgbụgbọ na nasopharyngitis.

Ndị ọrịa na-emecha akụkụ abụọ nke ikpe ahụ na-aga n'ihu ma ọ bụ gbanwee na Otezla n'oge mgbatị mgbatị nke ọmụmụ ahụ ma a ga-agwọ ya site na izu 32. Ọmụmụ ihe na-aga n'ihu ma na-eme atụmatụ imecha na ọkara mbụ nke 2022.

A ga-edobe nsonaazụ zuru ezu site na izu iri na isii nke akụkụ abụọ kpuru ìsì nke ọmụmụ ihe maka ngosi na ogbako ahụike na-abịa.

Na US, a kwadoro Otezla maka ọgwụgwọ nke ndị okenye nwere psoriasis dị oke oke ma dị njọ bụ ndị na-achọ maka phototherapy ma ọ bụ usoro ọgwụgwọ usoro, ndị okenye nwere ọrịa ogbu na nkwonkwo na-arụsi ọrụ ike na ndị okenye nwere ọnya ọnụ nke metụtara Behçet's Disease. Ebe ọ bụ na nkwado FDA mbụ ya na 2014, e debere Otezla ka ọ bụrụ ndị ọrịa 650,000 n'ụwa nile nwere psoriasis plaque na-agafeghị oke na nke siri ike, ọrịa ogbu na nkwonkwo psoriatic na-arụ ọrụ ma ọ bụ Ọrịa Behçet.

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Banyere chepụtara

Linda Hohnholz, onye editọ eTN

Linda Hohnholz na-ede ma na-edezi isiokwu kemgbe ọ malitere ọrụ ya. O tinyela obi uto nke a dika ebe Hawaii Pacific University, Chaminade University, Hawaii Discovery Center, ma ugbu a TravelNewsGroup.

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